Million Dollar Bike Ride

Roll with us … sign-up or donate today

Whether you can join us in Philadelphia on June 14, choose to ride remotely, or help out by donating, we are rolling for research as Lulu’s Crew Team STXBP1 in the Million Dollar Bike Ride in Philadelphia on June 14, 2025.

This annual fundraiser, hosted by the Orphan Disease Center of the University of Pennsylvania School of Medicine, welcomes more than 40 teams for patient advocacy organizations like ours to ride for a cure, promote awareness, and raise significant funds by doubling donations!

Thanks to the hard work of STXBP1 parents Erin and Ben Prosser, who push the pedal to rally our community for this ride each year, more than $900,000 has been raised over the past six years to fund seed grants for important research that is making a difference for our community. And with this year’s ride and your help, Lulu’s Crew plans to break the $1 Million fundraising milestone.

The dollars you help Lulu’s Crew Team STXBP1 raise between now and the ride are matched dollar-for-dollar up to $30,000 by the Orphan Disease Center, and tallied after the event. Researchers—who are working for treatments and cures of our STXers every single day—apply for seed grants, and the scientific advisory board of the STXBP1 Foundation weighs in on the decision for the grant awardees. 

You can help by riding, donating, and cheering them on. Click here to learn more about this year’s ride.

The Million Dollar Bike Ride is a signature event for the STXBP1-related disorders community.

The annual challenge brings over 750 fundraising-cyclists and volunteers to the University of Pennsylvania’s campus to ride 10, 32 or 70 miles around University City, Philadelphia. Teams can enter to represent individual rare diseases and receive matching funds for research into those conditions. The full amount raised goes to support the annual research grants.

Read about the origins of the ride in this article to learn more.